Cyclin D1 (CCND1) Peptide
CCND1
适用: 哺乳动物
宿主: 合成
BP, WB, IHC
Quick Overview for Cyclin D1 (CCND1) Peptide (ABIN939653)
抗原
Cyclin D1 (CCND1)
宿主
哺乳动物
资源
合成
应用范围
Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
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蛋白类型
- Synthetic
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序列
- KCEEEVFPLA MNYLDRFLSL EPVKKSRLQL LGATCMFVAS KMKETIPLTA
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产品特性
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A synthetic peptide for use as a blocking control in assays to test for specificity of CCND1 antibody,
Alternative Names: CCND1 control peptide, CCND1 antibody Blocking Peptide, Anti-CCND1 Blocking Peptide, cyclin D1 Blocking Peptide, BCL1 Blocking Peptide, D11S287E Blocking Peptide, PRAD1 Blocking Peptide, U21B31 Blocking Peptide, CCND1, CCND-1, CCND 1, CCND-1 Blocking Peptide, CCND 1 Blocking Peptide
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应用备注
- Optimal conditions should be determined by the investigator
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 100 µL of distilled water for a final peptide concentration is 1 mg/mL.
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缓冲液
- PBS
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注意事项
- Avoid repeated freeze/thaw cycles.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C long term.
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- Cyclin D1 (CCND1)
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背景
- CCND1 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. CCND1 has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.
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分子量
- 34 kDa
抗原
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