A synthetic peptide for use as a blocking control in assays to test for specificity of TGIF1 antibody, Alternative Names: TGIF1 control peptide, TGIF1 antibody Blocking Peptide, Anti-TGIF1 Blocking Peptide, Tgfb-Induced Factor Homeobox 1 Blocking Peptide, HPE4 Blocking Peptide, MGC39747 Blocking Peptide, MGC5066 Blocking Peptide, TGIF Blocking Peptide, TGIF1, TGIF-1, TGIF 1, TGIF-1 Blocking Peptide, TGIF 1 Blocking Peptide
Optimal conditions should be determined by the investigator
限制
仅限研究用
状态
Lyophilized
溶解方式
Add 100 µL of distilled water for a final peptide concentration is 1 mg/mL.
缓冲液
PBS
注意事项
Avoid repeated freeze/thaw cycles.
储存条件
-20 °C
储存方法
Store at -20 °C long term.
抗原
TGIF1
(TGFB-Induced Factor Homeobox 1 (TGIF1))
背景
TGIF1 is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element, the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals during development and in the adult. Mutations in this gene are associated with holoprosencephaly type 4, which is a structural anomaly of the brain.