Non-POU Domain Containing, Octamer-Binding (NONO) Peptide
NONO
适用: 哺乳动物
宿主: 合成
BP, WB, IHC
Quick Overview for Non-POU Domain Containing, Octamer-Binding (NONO) Peptide (ABIN937355)
抗原
NONO
(Non-POU Domain Containing, Octamer-Binding (NONO))
宿主
哺乳动物
资源
合成
应用范围
Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
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蛋白类型
- Synthetic
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序列
- DGTLGLTPPT TERFGQAATM EGIGAIGGTP PAFNRAAPGA EFAPNKRRRY
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产品特性
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A synthetic peptide for use as a blocking control in assays to test for specificity of NONO antibody,
Alternative Names: NONO control peptide, NONO antibody Blocking Peptide, Anti-NONO Blocking Peptide, Non-Pou Domain Containing Octamer-Binding Blocking Peptide -
纯化方法
- The antibody is affinity-purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen.
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应用备注
- Optimal conditions should be determined by the investigator
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 100 µL of distilled water for a final peptide concentration is 1 mg/mL.
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缓冲液
- PBS
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注意事项
- Avoid repeated freeze/thaw cycles.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C long term.
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- NONO (Non-POU Domain Containing, Octamer-Binding (NONO))
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背景
- NONO is DNA- and RNA binding protein, involved in several nuclear processes. It binds the conventional octamer sequence in double stranded DNA. It also binds single-stranded DNA and RNA at a site independent of the duplex site. It is involved in pre-mRNA splicing and interacts with U5 snRNA. The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs, be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1 and be involved in DNA nonhomologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends. NONO binds to an enhancer element in long terminal repeats of endogenous intracisternal A particles (IAPs) and activates transcription.
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分子量
- 52 kDa
抗原
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