A synthetic peptide for use as a blocking control in assays to test for specificity of OGG1 antibody, Alternative Names: OGG1 control peptide, OGG1 antibody Blocking Peptide, Anti-OGG1 Blocking Peptide, 8-oxoguanine DNA glycosylase Blocking Peptide, HMMH Blocking Peptide, HOGG1 Blocking Peptide, MUTM Blocking Peptide, OGH1 Blocking Peptide, OGG1, OGG-1, OGG 1, OGG-1 Blocking Peptide, OGG 1 Blocking Peptide
This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization.