A synthetic peptide for use as a blocking control in assays to test for specificity of PSMD3 antibody, Alternative Names: PSMD3 control peptide, PSMD3 antibody Blocking Peptide, Anti-PSMD3 Blocking Peptide, proteasome, prosome, macropain 26S subunit, non-ATPase, 3 Blocking Peptide, P58 Blocking Peptide, RPN3 Blocking Peptide, S3 Blocking Peptide, PSMD3, PSMD-3, PSMD 3, PSMD-3 Blocking Peptide, PSMD 3 Blocking Peptide
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits, 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid.