Catechol-O-Methyltransferase (COMT) (AA 51-271) Peptide
COMT
适用: 人
宿主: 大肠杆菌（E. Coli）
SDS
1 image
产品编号 ABIN935019
发货至:
中国
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Contact Info
Our Local Distributor
中国
北京 101111
北京 101111
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Quick Overview for Catechol-O-Methyltransferase (COMT) (AA 51-271) Peptide (ABIN935019)
抗原
COMT
(Catechol-O-Methyltransferase (COMT))
宿主
人
资源
大肠杆菌（E. Coli）
应用范围
SDS-PAGE (SDS)
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蛋白类型
- Recombinant
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蛋白结构域
- AA 51-271
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序列
- MGDTKEQRIL NHVLQHAEPG NAQSVLEAID TYCEQKEWAM NVGDKKGKIV DAVIQEHQPS VLLELGAYCG YSAVRMARLL SPGARLITIE INPDCAAITQ RMVDFAGVKD KVTLVVGASQ DIIPQLKKKY DVDTLDMVFL DHWKDRYLPD TLLLEECGLL RKGTVLLADN VICPGAPDFL AHVRGSSCFE CTHYQSFLEY REVVDGLEKA IYKGPGSEAG P
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产品特性
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Purified recombinant Human COMT protein
Expression System: E.coli
Molecular weight on SDS-PAGE will appear higher. -
纯度
- > 95 % pure
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内毒素水平
- < 1.0 EU per µg of protein (determined by LAL method)
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应用备注
- COMT protein has been used in SDS PAGE and may be suitable for use in other assays to be determined by the end user.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Supplied as a liquid in 20 mM Tris-HCl buffer, pH 8.0, containing 0 mM MgCl2, and 10 % glycerol.
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注意事项
- Avoid repeated freeze/thaw cycles.
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储存条件
- RT/-20 °C
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储存方法
- Store at 4 °C for short term storage (1/2 weeks). Aliquot and store at -20 °C or - 70 °C for long term storage.
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- COMT (Catechol-O-Methyltransferase (COMT))
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背景
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Catechol-O-methyltrasferase (COMT) is an enzyme that catalyses the transfer of the methyl group of S-adenosylmethionine (SAM) into catechol substrates such as levodopa, dopamine, epinephrine, and norepinephirine in the presence of Mg2+. COMT appears to be located in the postsynaptic neuron and plays roles in the metabolism of catechol estrogens and the inactivation of catecholamine neurotransmitters though enzymatic degradation. COMT inhibitors prevent levodopa degradation, increase its availability and are used in the treatment of patients with Parkinson's disease. Recombinant human COMT protein was expressed in E. coli and purified by using conventional chromatography techniques.
Alternative Names: Catechol-O-methyltransferase protein, COMT, Catechol-O-methyltransferase protein -
分子量
- 24.4 kDa (221 AA)
抗原
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