Fas Ligand Inhibitor Peptide
适用: 人, 小鼠, 大鼠
Func
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- 抗原
- Fas Ligand Inhibitor
- 宿主
- 人, 小鼠, 大鼠
- 应用范围
- Functional Studies (Func)
- 特异性
- Inhibits the apoptosis-inducing activity of Fas Ligand. Binds FasL (APO-1L, CD95L, CD178).
- 产品特性
- Extracellular domain of human Fas (aa. 7-154) fused to Fc portion of human IgG1.
- 纯度
- 95 % as determined by SDS-PAGE
- 内毒素水平
- <0.1 EU/µg purified protein as determined by LAL test.
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- 应用备注
- Functional Application: Inhibition of FAS Ligand activity in human and mouse: The apoptosis-inducing activity of FasL is inhibited by concentrations of 20-100 µg/mL of the fusion protein. Concentrations of Fas Ligand Inhibitor required to inhibit may vary depending on the cell viability and on the concentrations of sFasL used to kill the cells.
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Reconstitute with 50 µL sterile water to produce a 1 mg/mL solution in PBS. Further dilutions should be made with medium containing 5% fetal calf serum (FCS) or a carrier protein.
- 缓冲液
- PBS
- 储存条件
- -20 °C
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- 抗原
- Fas Ligand Inhibitor
- 背景
- Fas is a 45 kDa type I transmembrane protein belonging to the TNF receptor family. Fas contains 3 cysteine-rich repeats in the extracellular portion and a cytoplasmic motif called the `death domain' (DD). Death signals are triggered upon binding to its trimeric ligand FasL which induces oligomerization of Fas. The DD associates with FADD, which in turn connects to aspartate-specific proteases (caspases) that are implicated as mediators of most types of apoptotic cell death. Synonyms: APO-1, CD95, TNFRSF 6
- 分子量
- 45 kDa
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