Presenilin 2 (Alzheimer Disease 4) (PSEN2) (Middle Region) Peptide
Our Local Distributor
北京 101111
Quick Overview for Presenilin 2 (Alzheimer Disease 4) (PSEN2) (Middle Region) Peptide (ABIN8108893)
抗原
宿主
资源
应用范围
-
-
蛋白结构域
- Middle Region
-
原理
- PSEN2 Peptide - middle region
-
序列
- ALVFIKYLPE WSAWVILGAI SVYDLVAVLC PKGPLRMLVE TAQERNEPIF
-
-
Presenilin 2 (Alzheimer Disease 4) (PSEN2) peptide
PSEN2 宿主: 合成 BP, WB, IHC
-
-
应用备注
- Optimal working dilution should be determined by the investigator.
-
说明
-
This is a synthetic peptide designed for use in combination with anti- PSEN2 Antibody (ARP97209_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- Add 100 µL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
-
缓冲液
- Lyophilized powder
-
储存条件
- -20 °C
-
储存方法
- For longer periods of storage, store at -20 °C. Avoid repeat freeze-thaw cycles.
-
-
- Presenilin 2 (PSEN2) (Presenilin 2 (Alzheimer Disease 4) (PSEN2))
-
背景
-
Background Information: This gene encodes a member of the presenilin family. Presenilins are catalytic components of the multi-subunit gamma-secretase complex, which mediates critical cellular processes through cleavage of type I transmembrane proteins including Notch receptors and the amyloid precursor protein. The encoded protein contains eight transmembrane domains and is localized to the endoplasmic reticulum, where it may play a role in calcium homeostasis. Following assembly of the gamma-secretase complex, the encoded protein is cleaved into N- and C-terminal fragments and the activated complex is released from the endoplasmic reticulum. Inactivation of this gene results in impaired synaptic function in a mouse model for Alzheimer's disease. Alternatively spliced transcript variants have been observed for this gene.
Alternative Symbols: presenilin-2
-
分子量
- 50 kDa
-
基因ID
- 19165
-
NCBI登录号
- NP_001122077
-
UniProt
- Q61144
抗原
-
