Mitogen-Activated Protein Kinase Kinase Kinase 5 (MAP3K5) (Middle Region) Peptide
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Quick Overview for Mitogen-Activated Protein Kinase Kinase Kinase 5 (MAP3K5) (Middle Region) Peptide (ABIN8105672)
抗原
宿主
资源
应用范围
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蛋白结构域
- Middle Region
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原理
- MAP3K5 Peptide - middle region
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序列
- IRTLFLGIPD ENFEDHSAPP SPEEKDSGFF MLRKDSERRA TLHRILTEDQ
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应用备注
- Optimal working dilution should be determined by the investigator.
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说明
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This is a synthetic peptide designed for use in combination with anti- MAP3K5 Antibody (ARP87397_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 100 µL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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缓冲液
- Lyophilized powder
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储存条件
- -20 °C
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储存方法
- For longer periods of storage, store at -20 °C. Avoid repeat freeze-thaw cycles.
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- ASK1 (MAP3K5) (Mitogen-Activated Protein Kinase Kinase Kinase 5 (MAP3K5))
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背景
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Background Information: Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells, MAPKKK5 does not activate MAPK/ERK.
Alternative Symbols: ASK1, MEKK5, MAPKKK5
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分子量
- 68 kDa
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基因ID
- 4217
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NCBI登录号
- NP_005914
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UniProt
- Q99683
抗原
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