Minichromosome Maintenance Deficient 4 (MCM4) Peptide
Our Local Distributor
北京 101111
Quick Overview for Minichromosome Maintenance Deficient 4 (MCM4) Peptide (ABIN8105446)
抗原
资源
应用范围
-
-
原理
- MCM4 Peptide
-
-
-
-
应用备注
- Optimal working dilution should be determined by the investigator.
-
说明
-
This is a synthetic peptide designed for use in combination with anti-MCM4 antibody ( ARP36649_T100). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- Add 100 µL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
-
缓冲液
- Lyophilized powder
-
储存条件
- -20 °C
-
储存方法
- For longer periods of storage, store at -20 °C. Avoid repeat freeze-thaw cycles.
-
-
- MCM4 (Minichromosome Maintenance Deficient 4 (MCM4))
-
背景
-
Background Information: The protein encoded by MCM4 is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. The MCM4 gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks.
Alternative Symbols: CDC21, CDC54, hCdc21, P1-CDC21
-
分子量
- 95kDa
-
基因ID
- 4173
-
NCBI登录号
- NP_005905
-
UniProt
- P33991
抗原
-
