Minichromosome Maintenance Complex Component 7 (MCM7) Peptide
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Quick Overview for Minichromosome Maintenance Complex Component 7 (MCM7) Peptide (ABIN8105439)
抗原
资源
应用范围
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原理
- MCM7 Peptide
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应用备注
- Optimal working dilution should be determined by the investigator.
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说明
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This is a synthetic peptide designed for use in combination with anti-MCM7 antibody ( ARP36652_T100). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 100 µL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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缓冲液
- Lyophilized powder
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储存条件
- -20 °C
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储存方法
- For longer periods of storage, store at -20 °C. Avoid repeat freeze-thaw cycles.
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- MCM7 (Minichromosome Maintenance Complex Component 7 (MCM7))
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背景
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Background Information: MCM7 encodes a protein that is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme.The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
Alternative Symbols: MCM2, CDC47, P85MCM, P1CDC47, PNAS146, P1.1-MCM3
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分子量
- 81kDa
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基因ID
- 4176
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NCBI登录号
- NP_005907
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UniProt
- P33993
抗原
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