Guanine Nucleotide Binding Protein (G Protein) alpha 12 (GNA12) (Middle Region) Peptide
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Quick Overview for Guanine Nucleotide Binding Protein (G Protein) alpha 12 (GNA12) (Middle Region) Peptide (ABIN8102032)
抗原
宿主
资源
应用范围
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蛋白结构域
- Middle Region
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原理
- GNA12 Peptide - middle region
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序列
- IILFLNKMDL LVEKVKTVSI KKHFPDFRGD PHRLEDVQRY LVQCFDRKRR
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应用备注
- Optimal working dilution should be determined by the investigator.
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说明
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This is a synthetic peptide designed for use in combination with anti- GNA12 Antibody (ARP86929_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 100 µL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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缓冲液
- Lyophilized powder
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储存条件
- -20 °C
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储存方法
- For longer periods of storage, store at -20 °C. Avoid repeat freeze-thaw cycles.
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- GNA12 (Guanine Nucleotide Binding Protein (G Protein) alpha 12 (GNA12))
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背景
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Background Information: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF12/LARG. GNA12-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1) (By similarity). GNA12-dependent Rho signaling also regulates protein phosphatese 2A activation causing dephosphorylation of its target proteins. Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway and up-regulating proinflammatory cytokine production. Inhibits CDH1-mediated cell adhesion in process independent from Rho activation. Together with NAPA promotes CDH5 localization to plasma membrane. May play a role in the control of cell migration through the TOR signaling cascade.
Alternative Symbols: RMP, gep, NNX3
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分子量
- 41 kDa
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基因ID
- 2768
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NCBI登录号
- NP_001269370
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UniProt
- Q03113
抗原
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