erythrocyte Membrane Protein Band 4.9 (Dematin) (EPB49) (Middle Region) Peptide
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Quick Overview for erythrocyte Membrane Protein Band 4.9 (Dematin) (EPB49) (Middle Region) Peptide (ABIN8099821)
抗原
宿主
资源
应用范围
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蛋白结构域
- Middle Region
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原理
- DMTN Peptide - middle region
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序列
- SLPAYGRTTL SRLQSTEFSP SGSETGSPGL QNGEGQRGRM DRGNSLPCVL
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应用备注
- Optimal working dilution should be determined by the investigator.
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说明
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This is a synthetic peptide designed for use in combination with anti- EPB49 Antibody (ARP79851_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 100 µL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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缓冲液
- Lyophilized powder
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储存条件
- -20 °C
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储存方法
- For longer periods of storage, store at -20 °C. Avoid repeat freeze-thaw cycles.
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- Dematin (EPB49) (erythrocyte Membrane Protein Band 4.9 (Dematin) (EPB49))
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背景
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Background Information: The protein encoded by this gene is an actin binding and bundling protein that plays a structural role in erythrocytes, by stabilizing and attaching the spectrin/actin cytoskeleton to the erythrocyte membrane in a phosphorylation-dependent manner. This protein contains a core domain in the N-terminus, and a headpiece domain in the C-terminus that binds F-actin. When purified from erythrocytes, this protein exists as a trimer composed of two 48 kDa polypeptides and a 52 kDa polypeptide. The different subunits arise from alternative splicing in the 3' coding region, where the headpiece domain is located. Disruption of this gene has been correlated with the autosomal dominant Marie Unna hereditary hypotrichosis disease, while loss of heterozygosity of this gene is thought to play a role in prostate cancer progression. Alternative splicing results in multiple transcript variants encoding different isoforms.
Alternative Symbols: DMT, EPB49
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分子量
- 40 kDa
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基因ID
- 2039
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NCBI登录号
- NP_001107607
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UniProt
- Q08495
抗原
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