Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL) (C-Term) Peptide
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Quick Overview for Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL) (C-Term) Peptide (ABIN8096289)
抗原
宿主
资源
应用范围
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蛋白结构域
- C-Term
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原理
- CBL Peptide - C-terminal region
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序列
- GEGNLAAAHA NTGPEESENE DDGYDVPKPP VPAVLARRTL SDISNASSSF
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Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL) peptide
CBL 适用: 人, 小鼠, 大鼠, Cow, 犬, Pig 宿主: 合成 BP, Imm
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应用备注
- Optimal working dilution should be determined by the investigator.
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说明
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This is a synthetic peptide designed for use in combination with anti- CBL Antibody (ARP35761_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 100 µL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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缓冲液
- Lyophilized powder
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储存条件
- -20 °C
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储存方法
- For longer periods of storage, store at -20 °C. Avoid repeat freeze-thaw cycles.
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- CBL (Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL))
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背景
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Background Information: This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia. Mutations in this gene are also the cause of Noonan syndrome-like disorder.
Alternative Symbols: CBL2, NSLL, C-CBL, RNF55, FRA11B
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分子量
- 99 kDa
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基因ID
- 867
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NCBI登录号
- NP_005179
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UniProt
- P22681
抗原
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