产品编号 ABIN7582152
发货至:
中国
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Contact Info
Our Local Distributor
中国
北京 101111
北京 101111
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Beijing Economic Technological Development Area
Room 801-803
Quick Overview for omega-Conotoxin SVIB Peptide (ABIN7582152)
抗原
omega-Conotoxin SVIB
宿主
Conus striatus (Striated cone)
资源
合成
应用范围
Blocking Peptide (BP)
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蛋白类型
- Synthetic
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原理
- A Potent Blocker of N-Type CaV Channels
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序列
- CKLKGQSCRK TSYDCCSGSC GRSGKC-NH2
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特异性
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Toxin target: N-Type CaV channels,
Disulfide bonds between: Cys1-Cys16, Cys8-Cys20, and Cys15-Cys26 Cys26 - C-terminal amidation -
产品特性
- A Potent Blocker of N-Type CaV Channels
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纯度
- ≥98 % (HPLC)
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应用备注
- Antigen Preadsorption Control: 10 - 50 nM
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Centrifuge the vial (10,000 x g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing, light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 μM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20 °C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
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缓冲液
- Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.
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储存条件
- 4 °C,-20 °C
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储存方法
- The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.,The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.
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- omega-Conotoxin SVIB
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背景
- SNX-183,ω-Conotoxin SVIB, an analogue of ω-conotoxin GVIA, is a peptide toxin originally isolated from Conus striatus venoM It is a potent blocker of N-type voltage-gated Ca2+ channels. It has an analgesic effect and is being used as a potential drug for the treatment of chronic and neuropathic pain models1,2.ω-Conotoxins are disulfide-rich peptides comprises 24-31 amino acids, isolated from the venom of marine predatory cone snails. These conotoxins have a high content of basic amino acid residue and a common cysteine scaffold that stabilizes the four-loop framework2,3.Voltage-gated N-Type Ca2+ channels are predominantly expressed in nerve terminals and are involved in the regulation of neuronal excitability and nociceptive signals. These channels play an important role in the transduction of acute and chronic pain perception. They are able to transduce electrical activity into other cellular functions and regulate calcium homeostasis3.
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分子量
- 2739 Da
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UniProt
- P28881
抗原
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