Galanin-Like Peptide (GALP) Peptide
GALP
适用: 人
宿主: 合成
BP, Func
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- 抗原 See all GALP products
- GALP (Galanin-Like Peptide (GALP))
- 蛋白类型
- Synthetic
- 宿主
- 人
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资源
- 合成
- 应用范围
- Blocking Peptide (BP), Functional Studies (Func)
- 原理
- A Non-Selective and Potent Agonist of Galanin Receptors
- 序列
- AHRGRGGWTL NSAGYLLGPV LHLPQMGDQ-OH
- 特异性
- Toxin target: Galanin receptors
- 产品特性
- A Non-Selective and Potent Agonist of Galanin Receptors
- 纯度
- ≥98 % (HPLC)
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- 应用备注
- Antigen Preadsorption Control: 1 - 50 nM
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Centrifuge the vial (10,000 x g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing, light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 μM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20 °C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
- 缓冲液
- Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.,The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.
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- 抗原
- GALP (Galanin-Like Peptide (GALP))
- 背景
- Galanin-like peptide (3-32),Human GALP (3-32) fragment is a human galanin-like peptide that acts as a non-selective and potent galanin receptor agonist. Human GALP consists of 60 amino acid with a potential proteolytic cleavage site between two basic amino acids in position 33.Human GALP (3-32) shares amino acids in position 9-21 with the first 13 amino acids of galanin, an essential sequence for activating galanin receptors1,2. Galanin receptors belong to the family of G-protein coupled receptors and consist of three subtypes: GalR1, GalR2, and GalR3.Human GALP (3-32) is at least as potent as full length GALP. Studies suggest that GALP (3-32) fragment can represent the strongest mediator of biological GALP activity. GALP (3-32) can be used as a useful tool for studding the affinity of GALP to galanin receptors and to search for specific GALP receptors1,2. Human GALP (3-32) displays highest affinity to GalR3 with an IC50 value of 10 nM, followed by GalR2 with IC50 of 28 nM and GalR1 with IC50 of 77 nM1.
- 分子量
- 3102 Da
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