Isocitrate Dehydrogenase 1 (NADP+), Soluble (IDH1) (Middle Region) Peptide
IDH1
适用: 人
宿主: 合成
BP, WB
产品编号 ABIN5673123
发货至:
中国
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Contact Info
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Quick Overview for Isocitrate Dehydrogenase 1 (NADP+), Soluble (IDH1) (Middle Region) Peptide (ABIN5673123)
抗原
IDH1
(Isocitrate Dehydrogenase 1 (NADP+), Soluble (IDH1))
宿主
人
资源
合成
应用范围
Blocking Peptide (BP), Western Blotting (WB)
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蛋白结构域
- Middle Region
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序列
- EAAHGTVTRH YRMYQKGQET STNPIASIFA WTRGLAHRAK LDNNKELAFF
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产品特性
- This is a synthetic peptide designed for use in combination with anti- IDH1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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储存条件
- -20 °C
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储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- IDH1 (Isocitrate Dehydrogenase 1 (NADP+), Soluble (IDH1))
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背景
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Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production. Alternatively spliced transcript variants encoding the same protein have been found for this gene.
Alias Symbols: IDH, IDP, IDCD, IDPC, PICD, HEL-216, HEL-S-26
Protein Size: 414 -
基因ID
- 3417
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NCBI登录号
- NM_001282386, NP_001269315
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UniProt
- O75874
抗原
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