Guanine Nucleotide Binding Protein (G Protein) alpha 12 (GNA12) (Middle Region) Peptide
GNA12
适用: 人
宿主: 合成
BP, WB
产品编号 ABIN5673091
发货至:
中国
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Quick Overview for Guanine Nucleotide Binding Protein (G Protein) alpha 12 (GNA12) (Middle Region) Peptide (ABIN5673091)
抗原
GNA12
(Guanine Nucleotide Binding Protein (G Protein) alpha 12 (GNA12))
宿主
人
资源
合成
应用范围
Blocking Peptide (BP), Western Blotting (WB)
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蛋白结构域
- Middle Region
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序列
- IILFLNKMDL LVEKVKTVSI KKHFPDFRGD PHRLEDVQRY LVQCFDRKRR
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产品特性
- This is a synthetic peptide designed for use in combination with anti- GNA12 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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储存条件
- -20 °C
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储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- GNA12 (Guanine Nucleotide Binding Protein (G Protein) alpha 12 (GNA12))
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背景
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Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF12/LARG. GNA12-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1) (By similarity). GNA12-dependent Rho signaling also regulates protein phosphatese 2A activation causing dephosphorylation of its target proteins. Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway and up-regulating proinflammatory cytokine production. Inhibits CDH1-mediated cell adhesion in process independent from Rho activation. Together with NAPA promotes CDH5 localization to plasma membrane. May play a role in the control of cell migration through the TOR signaling cascade.
Alias Symbols: RMP, gep, NNX3
Protein Size: 381 -
基因ID
- 2768
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NCBI登录号
- NM_001282441, NP_001269370
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UniProt
- Q03113
抗原
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