Itchy E3 Ubiquitin Protein Ligase Homolog (ITCH) (Middle Region) Peptide
ITCH
适用: 人
宿主: 合成
BP, WB
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- 抗原 See all ITCH products
- ITCH (Itchy E3 Ubiquitin Protein Ligase Homolog (ITCH))
- 蛋白结构域
- Middle Region
- 宿主
- 人
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资源
- 合成
- 应用范围
- Blocking Peptide (BP), Western Blotting (WB)
- 序列
- KPSRPPRPSR PPPPTPRRPA SVNGSPSATS ESDGSSTGSL PPTNTNTNTS
- 产品特性
- This is a synthetic peptide designed for use in combination with anti- ITCH Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- 储存条件
- -20 °C
- 储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- 抗原
- ITCH (Itchy E3 Ubiquitin Protein Ligase Homolog (ITCH))
- 背景
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This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein plays a role in multiple cellular processes including erythroid and lymphoid cell differentiation and the regulation of immune responses. Mutations in this gene are a cause of syndromic multisystem autoimmune disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Alias Symbols: AIF4, AIP4, ADMFD, NAPP1
Protein Size: 752 - 基因ID
- 83737
- NCBI登录号
- NM_001257137, NP_001244066
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