Fibroblast Growth Factor Receptor 1 (FGFR1) (N-Term) Peptide
FGFR1
适用: 人
宿主: 合成
BP, WB
产品编号 ABIN5672560
发货至:
中国
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Contact Info
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Quick Overview for Fibroblast Growth Factor Receptor 1 (FGFR1) (N-Term) Peptide (ABIN5672560)
抗原
FGFR1
(Fibroblast Growth Factor Receptor 1 (FGFR1))
宿主
人
资源
合成
应用范围
Blocking Peptide (BP), Western Blotting (WB)
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蛋白结构域
- N-Term
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序列
- VTSSPSGSDT TYFSVNVSDA LPSSEDDDDD DDSSSEEKET DNTKPNRMPV
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产品特性
- This is a synthetic peptide designed for use in combination with anti- FGFR1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Fibroblast Growth Factor Receptor 1 (FGFR1) peptide
FGFR1 适用: 人, Cow, 犬 宿主: 合成 BP, Imm
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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储存条件
- -20 °C
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储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- FGFR1 (Fibroblast Growth Factor Receptor 1 (FGFR1))
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背景
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The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described, however, not all variants have been fully characterized.
Alias Symbols: CEK, FLG, HH2, OGD, ECCL, FLT2, KAL2, BFGFR, CD331, FGFBR, FLT-2, HBGFR, N-SAM, FGFR-1, HRTFDS, bFGF-R-1
Protein Size: 300 -
基因ID
- 2260
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NCBI登录号
- NM_001174063, NP_001167534
抗原
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