Eukaryotic Translation Initiation Factor 3, Subunit B (EIF3B) (N-Term) Peptide
EIF3B
适用: 人
宿主: 合成
BP, WB
产品编号 ABIN5672520
发货至:
中国
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Quick Overview for Eukaryotic Translation Initiation Factor 3, Subunit B (EIF3B) (N-Term) Peptide (ABIN5672520)
抗原
EIF3B
(Eukaryotic Translation Initiation Factor 3, Subunit B (EIF3B))
宿主
人
资源
合成
应用范围
Blocking Peptide (BP), Western Blotting (WB)
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蛋白结构域
- N-Term
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序列
- AAEELPGSHA EPPVPAQGEA PGEQARDERS DSRAQAVSED AGGNEGRAAE
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产品特性
- This is a synthetic peptide designed for use in combination with anti- EIF3B Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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储存条件
- -20 °C
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储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- EIF3B (Eukaryotic Translation Initiation Factor 3, Subunit B (EIF3B))
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背景
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RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.(Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2.
Alias Symbols: PRT1, EIF3S9, EIF3-ETA, EIF3-P110, EIF3-P116
Protein Size: 873 -
基因ID
- 8662
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NCBI登录号
- NM_001037283, NP_001032360
抗原
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