Pre-B-Cell Leukemia Homeobox Protein 1 (PBX1) (Middle Region) Peptide
PBX1
适用: 人
宿主: 合成
BP, WB
Quick Overview for Pre-B-Cell Leukemia Homeobox Protein 1 (PBX1) (Middle Region) Peptide (ABIN5672304)
抗原
PBX1
(Pre-B-Cell Leukemia Homeobox Protein 1 (PBX1))
宿主
人
资源
合成
应用范围
Blocking Peptide (BP), Western Blotting (WB)
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蛋白结构域
- Middle Region
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序列
- GSQANSPSTP NSAGSSSSFN MSNSGDLFMS VQSLNGDSYQ GAQVGANVQS
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产品特性
- This is a synthetic peptide designed for use in combination with anti- PBX1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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储存条件
- -20 °C
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储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- PBX1 (Pre-B-Cell Leukemia Homeobox Protein 1 (PBX1))
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背景
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This gene encodes a nuclear protein that belongs to the PBX homeobox family of transcriptional factors. Studies in mice suggest that this gene may be involved in the regulation of osteogenesis, and required for skeletal patterning and programming. A chromosomal translocation, t(1,19) involving this gene and TCF3/E2A gene, is associated with pre-B-cell acute lymphoblastic leukemia. The resulting fusion protein, in which the DNA binding domain of E2A is replaced by the DNA binding domain of this protein, transforms cells by constitutively activating transcription of genes regulated by the PBX protein family. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Protein Size: 347 -
基因ID
- 5087
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NCBI登录号
- NM_001204963, NP_001191892
抗原
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