Methyl-CpG Binding Domain Protein 2 (MBD2) (Middle Region) Peptide
MBD2
适用: 人
宿主: 合成
BP, WB
Quick Overview for Methyl-CpG Binding Domain Protein 2 (MBD2) (Middle Region) Peptide (ABIN5671678)
抗原
MBD2
(Methyl-CpG Binding Domain Protein 2 (MBD2))
宿主
人
资源
合成
应用范围
Blocking Peptide (BP), Western Blotting (WB)
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蛋白结构域
- Middle Region
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序列
- ARYLGNTVDL SSFDFRTGKM MPSKLQKNKQ RLRNDPLNQN KGKPDLNTTL
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产品特性
- This is a synthetic peptide designed for use in combination with anti- MBD2 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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储存条件
- -20 °C
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储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- MBD2 (Methyl-CpG Binding Domain Protein 2 (MBD2))
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背景
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DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing. Two transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: DMTase, NY-CO-41
Protein Size: 302 -
基因ID
- 8932
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NCBI登录号
- NM_003927, NP_003918
抗原
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