V-Akt Murine Thymoma Viral Oncogene Homolog 2 (AKT2) Peptide
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Quick Overview for V-Akt Murine Thymoma Viral Oncogene Homolog 2 (AKT2) Peptide (ABIN5624574)
抗原
资源
应用范围
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蛋白类型
- Synthetic
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Supplier Product No.
- 000-001-j35
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Supplier
- Rockland
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原理
- AKT2 Control Peptide
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产品特性
- AKT 2, AKT-2, PKB, PKB beta, PKBBETA PRKBB, Protein kinase Akt 2, Protein kinase B beta, RAC-beta serine/threonine-protein kinase, RAC-PK-beta, blocking peptide
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纯化方法
- Purity was determined to be greater than 98% by analysis by RP-HPLC and by reducing and non-reducing SDS-PAGE.
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纯度
- Greater than 98% by analysis by RP-HPLC and by reducing and non-reducing SDS-PAGE.
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V-Akt Murine Thymoma Viral Oncogene Homolog 2 (AKT2) peptide
AKT2 宿主: 合成 WB, CP Sodium azide
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应用备注
- Optional[Flow Cytometry Dilution]: AKT2 Control peptide has been tested by western blot and is suitable as a control for polyclonal or monoclonal Anti-AKT2 in immunological assays.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
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Reconstitution Buffer: Restore with deionized water (or equivalent)
Reconstitution Volume: 50μL
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浓度
- 1.0 mg/mL
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缓冲液
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Buffer: None
Stabilizer: None
Preservative: 0.01 % (w/v) Sodium Azide -
储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store vial at 2-8 °C prior to opening. Aliquot contents and freeze at -20 °C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. Dilute only prior to immediate use.
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有效期
- 6 months
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- AKT2 (V-Akt Murine Thymoma Viral Oncogene Homolog 2 (AKT2))
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背景
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Synonyms: AKT 2, AKT-2, PKB, PKB beta, PKBBETA PRKBB, Protein kinase Akt 2, Protein kinase B beta, RAC-beta serine/threonine-protein kinase, RAC-PK-beta, blocking peptide
Background: AKT2 peptide detects AKT2 which is a component of the PI-3 kinase pathway and is activated by phosphorylation at Ser 473 and Thr 308. AKT is a cytoplasmic protein also known as Protein Kinase B (PKB) and rac (related to A and C kinases). AKT is a key regulator of many signal transduction pathways. AKT Exhibits tight control over cell proliferation and cell viability. Overexpression or inappropriate activation of AKT is noted in many types of cancer. AKT mediates many of the downstream events of PI 3-kinase (a lipid kinase activated by growth factors, cytokines and insulin). PI 3-kinase recruits AKT to the membrane, where it is activated by PDK1 phosphorylation. Once phosphorylated, AKT dissociates from the membrane and phosphorylates targets in the cytoplasm and the cell nucleus. AKT has two main roles: (i) inhibition of apoptosis, (ii) promotion of proliferation.
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基因ID
- 208
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UniProt
- P31751
抗原
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