Myelin Protein Zero (MPZ) (Middle Region) Peptide
MPZ
适用: 人
宿主: 合成
WB
Quick Overview for Myelin Protein Zero (MPZ) (Middle Region) Peptide (ABIN5518460)
抗原
MPZ
(Myelin Protein Zero (MPZ))
宿主
人
资源
合成
应用范围
Western Blotting (WB)
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蛋白结构域
- Middle Region
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序列
- AALQRRLSAM EKGKLHKPGK DASKRGRQTP VLYAMLDHSR STKAVSEKKA
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Myelin Protein Zero (MPZ) peptide
MPZ 适用: 人, 大鼠, 小鼠, 犬 宿主: 合成 BP, Imm
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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储存条件
- -20 °C
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储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- MPZ (Myelin Protein Zero (MPZ))
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背景
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This gene is specifically expressed in Schwann cells of the peripheral nervous system and encodes a type I transmembrane glycoprotein that is a major structural protein of the peripheral myelin sheath. The encoded protein contains a large hydrophobic extracellular domain and a smaller basic intracellular domain, which are essential for the formation and stabilization of the multilamellar structure of the compact myelin. Mutations in this gene are associated with autosomal dominant form of Charcot-Marie-Tooth disease type 1 (CMT1B) and other polyneuropathies, such as Dejerine-Sottas syndrome (DSS) and congenital hypomyelinating neuropathy (CHN). A recent study showed that two isoforms are produced from the same mRNA by use of alternative in-frame translation termination codons via a stop codon readthrough mechanism.
Alias Symbols: P0, CHM, DSS, MPP, CMT1, CMT1B, CMT2I, CMT2J, CMT4E, CMTDI3, CMTDID, HMSNIB
Protein Size: 248 -
基因ID
- 4359
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NCBI登录号
- NM_000530, NP_000521
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UniProt
- P25189
抗原
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