The protein encoded by this gene is a member of the SMAD family, which transduces signals from TGF-beta family members. The encoded protein is activated by bone morphogenetic proteins and interacts with SMAD4. Two transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: PPH2, MADH6, MADH9, SMAD8, SMAD8A, SMAD8B