Wiskott-Aldrich Syndrome (Eczema-thrombocytopenia) (WAS) (N-Term) Peptide
WAS
适用: 人
宿主: 合成
BP, WB
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- 抗原 See all WASP (WAS) products
- WASP (WAS) (Wiskott-Aldrich Syndrome (Eczema-thrombocytopenia) (WAS))
- 蛋白结构域
- N-Term
- 宿主
- 人
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资源
- 合成
- 应用范围
- Blocking Peptide (BP), Western Blotting (WB)
- 序列
- IQKRNQRQSG DRRQLPPPPT PANEERRGGL PPLPLHPGGD QGGPPVGPLS
- 产品特性
- This is a synthetic peptide designed for use in combination with anti-WASP Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- 储存条件
- -20 °C
- 储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- 抗原
- WASP (WAS) (Wiskott-Aldrich Syndrome (Eczema-thrombocytopenia) (WAS))
- 别名
- IMD2 Peptide, SCNX Peptide, THC Peptide, THC1 Peptide, WASP Peptide, U42471 Peptide, WASp Peptide, Wasp Peptide, imd2 Peptide, thc Peptide, thc1 Peptide, was Peptide, wasp Peptide, wu:fk81c08 Peptide, zgc:64164 Peptide, Wiskott-Aldrich syndrome Peptide, neural Wiskott-Aldrich syndrome protein Peptide, wiskott-aldrich syndrome protein Peptide, Wiskott-Aldrich syndrome L homeolog Peptide, Wiskott-Aldrich syndrome (eczema-thrombocytopenia) b Peptide, WAS Peptide, LOC5578888 Peptide, CpipJ_CPIJ006699 Peptide, Was Peptide, was.L Peptide, wasb Peptide
- 背景
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The Wiskott-Aldrich syndrome (WAS) family of proteins share similar domain structure, and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. The presence of a number of different motifs suggests that they are regulated by a number of different stimuli, and interact with multiple proteins. Recent studies have demonstrated that these proteins, directly or indirectly, associate with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. Wiskott-Aldrich syndrome is a rare, inherited, X-linked, recessive disease characterized by immune dysregulation and microthrombocytopenia, and is caused by mutations in the WAS gene. The WAS gene product is a cytoplasmic protein, expressed exclusively in hematopoietic cells, which show signalling and cytoskeletal abnormalities in WAS patients. A transcript variant arising as a result of alternative promoter usage, and containing a different 5' UTR sequence, has been described, however, its full-length nature is not known.
Alias Symbols: WAS,IMD2,
Protein Size: 502 - 基因ID
- 7454
- NCBI登录号
- NP_000368
- UniProt
- P42768
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