Pyruvate Dehydrogenase (Lipoamide) alpha 1 (PDHA1) (Middle Region) Peptide
PDHA1
适用: 人
宿主: 合成
BP, WB
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- 抗原 See all PDHA1 products
- PDHA1 (Pyruvate Dehydrogenase (Lipoamide) alpha 1 (PDHA1))
- 蛋白结构域
- Middle Region
- 宿主
- 人
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资源
- 合成
- 应用范围
- Blocking Peptide (BP), Western Blotting (WB)
- 序列
- AASTDYYKRG DFIPGLRVDG MDILCVREAT RFAAAYCRSG KGPILMELQT
- 产品特性
- This is a synthetic peptide designed for use in combination with anti-PDHA1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- 储存条件
- -20 °C
- 储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- 抗原
- PDHA1 (Pyruvate Dehydrogenase (Lipoamide) alpha 1 (PDHA1))
- 背景
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The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 alpha 1 subunit containing the E1 active site, and plays a key role in the function of the PDH complex. Mutations in this gene are associated with pyruvate dehydrogenase E1-alpha deficiency and X-linked Leigh syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: PDHA, PDHAD, PHE1A, PDHCE1A
Protein Size: 390 - 基因ID
- 5160
- NCBI登录号
- NM_000284, NP_000275
- UniProt
- P08559
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