Caspase 8 (CASP8) (Middle Region) Peptide
CASP8
适用: 人
宿主: 合成
BP, WB
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- 抗原 See all Caspase 8 (CASP8) products
- Caspase 8 (CASP8)
- 蛋白结构域
- Middle Region
- 宿主
- 人
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资源
- 合成
- 应用范围
- Blocking Peptide (BP), Western Blotting (WB)
- 序列
- SPDEFSNGEE LCGVMTISDS PREQDSESQT LDKVYQMKSK PRGYCLIINN
- 产品特性
- This is a synthetic peptide designed for use in combination with anti-CASP8 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- 储存条件
- -20 °C
- 储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- 抗原
- Caspase 8 (CASP8)
- 别名
- casp8-A Peptide, xCaspase-8 Peptide, casp8 Peptide, CASP8 Peptide, CASP-8 Peptide, FLICE Peptide, MACH Peptide, Mch5 Peptide, ALPS2B Peptide, CAP4 Peptide, Casp-8 Peptide, MCH5 Peptide, caspase-8 Peptide, zgc:92075 Peptide, caspase 8 L homeolog Peptide, death related ced-3/Nedd2-like protein Peptide, caspase 8 Peptide, caspase-8 Peptide, caspase-8-like Peptide, caspase 8, apoptosis-related cysteine peptidase Peptide, casp8.L Peptide, LOC661095 Peptide, CASP8 Peptide, LOC5563818 Peptide, casp8 Peptide, LOC100222284 Peptide, Casp8 Peptide
- 背景
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This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined.
Alias Symbols: CAP4, MACH, MCH5, FLICE, ALPS2B, Casp-8
Protein Size: 538 - 基因ID
- 841
- NCBI登录号
- NM_001080124, NP_001073594
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