Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL) (C-Term) Peptide
CBL
适用: 人
宿主: 合成
BP, WB
产品编号 ABIN5512802
发货至:
中国
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Contact Info
Our Local Distributor
中国
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北京 101111
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Quick Overview for Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL) (C-Term) Peptide (ABIN5512802)
抗原
CBL
(Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL))
宿主
人
资源
合成
应用范围
Blocking Peptide (BP), Western Blotting (WB)
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蛋白结构域
- C-Term
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序列
- GEGNLAAAHA NTGPEESENE DDGYDVPKPP VPAVLARRTL SDISNASSSF
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产品特性
- This is a synthetic peptide designed for use in combination with anti- CBL Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL) peptide
CBL 适用: 人, 小鼠, 大鼠, Cow, 犬, Pig 宿主: 合成 BP, Imm
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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储存条件
- -20 °C
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储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- CBL (Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL))
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背景
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This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia. Mutations in this gene are also the cause of Noonan syndrome-like disorder.
Alias Symbols: CBL2, NSLL, C-CBL, RNF55, FRA11B
Protein Size: 906 -
基因ID
- 867
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NCBI登录号
- NM_005188, NP_005179
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UniProt
- P22681
抗原
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