Fms-Related tyrosine Kinase 3 (FLT3) (N-Term) Peptide
FLT3
适用: 人
宿主: 合成
BP, WB
产品编号 ABIN5512790
发货至:
中国
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Contact Info
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Quick Overview for Fms-Related tyrosine Kinase 3 (FLT3) (N-Term) Peptide (ABIN5512790)
抗原
FLT3
(Fms-Related tyrosine Kinase 3 (FLT3))
宿主
人
资源
合成
应用范围
Blocking Peptide (BP), Western Blotting (WB)
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蛋白结构域
- N-Term
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序列
- Synthetic peptide located within the following region: < a href='http://www.ncbi.nlm.nih.gov/blast/Blast.cgi?PROGRAM=blastp&CLIENT=web&SERVICE=plain&PAGE=Proteins&CMD=Put&DATABASE=nr&CDD_SEARCH=1&AUTO_FORMAT=Semi-auto&SHOW_OVERVIEW=on&SHOW_LINKOUT=on&GET_S
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产品特性
- This is a synthetic peptide designed for use in combination with anti-FLT3 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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储存条件
- -20 °C
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储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- FLT3 (Fms-Related tyrosine Kinase 3 (FLT3))
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背景
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This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.
Alias Symbols: FLK2, STK1, CD135, FLK-2
Protein Size: 952 -
基因ID
- 2322
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NCBI登录号
- NM_004119, NP_004110
抗原
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