Solute Carrier Family 19, Member 3 (Slc19a3) (C-Term) Peptide
Slc19a3
适用: 人
宿主: 合成
BP, WB
产品编号 ABIN5512660
发货至:
中国
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Quick Overview for Solute Carrier Family 19, Member 3 (Slc19a3) (C-Term) Peptide (ABIN5512660)
抗原
SLC19A3 (Slc19a3)
(Solute Carrier Family 19, Member 3 (Slc19a3))
宿主
人
资源
合成
应用范围
Blocking Peptide (BP), Western Blotting (WB)
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蛋白结构域
- C-Term
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序列
- VYGSYFAVIA GIFLMRSMYI TYSTKSQKDV QSPAPSENPD VSHPEEESNI
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产品特性
- This is a synthetic peptide designed for use in combination with anti-SLC19A3 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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储存条件
- -20 °C
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储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- SLC19A3 (Slc19a3) (Solute Carrier Family 19, Member 3 (Slc19a3))
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背景
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This gene encodes a ubiquitously expressed transmembrane thiamine transporter that lacks folate transport activity. Mutations in this gene cause biotin-responsive basal ganglia disease (BBGD), a recessive disorder manifested in childhood that progresses to chronic encephalopathy, dystonia, quadriparesis, and death if untreated. Patients with BBGD have bilateral necrosis in the head of the caudate nucleus and in the putamen. Administration of high doses of biotin in the early progression of the disorder eliminates pathological symptoms while delayed treatment results in residual paraparesis, mild mental retardation, or dystonia. Administration of thiamine is ineffective in the treatment of this disorder. Experiments have failed to show that this protein can transport biotin. Mutations in this gene also cause a Wernicke's-like encephalopathy.
Alias Symbols: BBGD, THMD2, THTR2
Protein Size: 496 -
基因ID
- 80704
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NCBI登录号
- NM_025243, NP_079519
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UniProt
- Q9BZV2
抗原
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