Chemokine (C-C Motif) Receptor 3 (CCR3) (C-Term) Peptide
CCR3
适用: 人
宿主: 合成
BP, WB
产品编号 ABIN5512183
发货至:
中国
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Contact Info
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Quick Overview for Chemokine (C-C Motif) Receptor 3 (CCR3) (C-Term) Peptide (ABIN5512183)
抗原
CCR3
(Chemokine (C-C Motif) Receptor 3 (CCR3))
宿主
人
资源
合成
应用范围
Blocking Peptide (BP), Western Blotting (WB)
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蛋白结构域
- C-Term
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序列
- ERFRKYLRHF FHRHLLMHLG RYIPFLPSEK LERTSSVSPS TAEPELSIVF
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产品特性
- This is a synthetic peptide designed for use in combination with anti- CCR3 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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储存条件
- -20 °C
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储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- CCR3 (Chemokine (C-C Motif) Receptor 3 (CCR3))
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背景
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The protein encoded by this gene is a receptor for C-C type chemokines. It belongs to family 1 of the G protein-coupled receptors. This receptor binds and responds to a variety of chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13), and RANTES (CCL5). It is highly expressed in eosinophils and basophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway. It is also known to be an entry co-receptor for HIV-1. This gene and seven other chemokine receptor genes form a chemokine receptor gene cluster on the chromosomal region 3p21. Alternatively spliced transcript variants have been described.
Alias Symbols: CKR3, CD193, CMKBR3, CC-CKR-3
Protein Size: 355 -
基因ID
- 1232
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NCBI登录号
- NM_001837, NP_001828
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UniProt
- P51677
抗原
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