Poly A Specific Ribonuclease (PARN) (Middle Region) Peptide
PARN
适用: 人
宿主: 合成
BP, WB
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- 抗原 See all PARN products
- PARN (Poly A Specific Ribonuclease (PARN))
- 蛋白结构域
- Middle Region
- 宿主
- 人
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资源
- 合成
- 应用范围
- Blocking Peptide (BP), Western Blotting (WB)
- 序列
- CQSSSIDFLA SQGFDFNKVF RNGIPYLNQE EERQLREQYD EKRSQANGAG
- 产品特性
- This is a synthetic peptide designed for use in combination with anti-PARN Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- 储存条件
- -20 °C
- 储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- 抗原
- PARN (Poly A Specific Ribonuclease (PARN))
- 背景
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The protein encoded by this gene is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mRNAs. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. This protein is also involved in silencing of certain maternal mRNAs during oocyte maturation and early embryonic development, as well as in nonsense-mediated decay (NMD) of mRNAs that contain premature stop codons. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: DAN, DKCB6, PFBMFT4
Protein Size: 639 - 基因ID
- 5073
- NCBI登录号
- NM_001134477, NP_001127949
- UniProt
- O95453
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