Ornithine Decarboxylase Antizyme 1 (OAZ1) (Middle Region) Peptide
OAZ1
适用: 小鼠
宿主: 合成
BP, WB
Quick Overview for Ornithine Decarboxylase Antizyme 1 (OAZ1) (Middle Region) Peptide (ABIN5511408)
抗原
OAZ1
(Ornithine Decarboxylase Antizyme 1 (OAZ1))
宿主
小鼠
资源
合成
应用范围
Blocking Peptide (BP), Western Blotting (WB)
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蛋白结构域
- Middle Region
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序列
- PHPPLKIPGG RGNSQRDHSL SASILYSDER LNVTEEPTSN DKTRVLSIQS
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产品特性
- This is a synthetic peptide designed for use in combination with anti-Oaz1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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储存条件
- -20 °C
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储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- OAZ1 (Ornithine Decarboxylase Antizyme 1 (OAZ1))
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背景
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The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis, thus, completing the auto-regulatory circuit. This gene encodes antizyme 1, the first member of the antizyme family, that has broad tissue distribution, and negatively regulates intracellular polyamine levels by binding to and targeting ODC for degradation, as well as inhibiting polyamine uptake. Antizyme 1 mRNA contains two potential in-frame AUGs, and studies in rat suggest that alternative use of the two translation initiation sites results in N-terminally distinct protein isoforms with different subcellular localization. Alternatively spliced transcript variants have also been noted for this gene.
Alias Symbols: AZ1, Oaz, AZ-1, ODC-Az, Antizyme
Protein Size: 227 -
基因ID
- 18245
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NCBI登录号
- NM_008753, NP_032779
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UniProt
- P54369
抗原
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