SET Nuclear Oncogene (SET) Peptide
SET
适用: 人
宿主: 兔
BP
产品编号 ABIN2764137
发货至:
中国
Contact our Customer Service for availability and price in your country.
Contact Info
Our Local Distributor
中国
北京 101111
北京 101111
No. 88 KeChuang 6th Street
Beijing Economic Technological Development Area
Room 801-803
Quick Overview for SET Nuclear Oncogene (SET) Peptide (ABIN2764137)
抗原
SET/TAF-I (SET)
(SET Nuclear Oncogene (SET))
宿主
人
资源
兔
应用范围
Blocking Peptide (BP)
-
-
-
-
限制
- 仅限研究用
-
-
-
储存条件
- -20 °C
-
-
- SET/TAF-I (SET) (SET Nuclear Oncogene (SET))
-
背景
- Human SET was originally identified as part of the SET-CAN fusion gene produced by a somatic translocation event in a patient with acute undifferentiated leukemia. In developing kidney, SET is highly expressed in the zone of nephron morphogenesis. SET has been shown to be a potent and specific inhibitor of protein phosphatase 2A, a family of major serine/threonine phosphatases involved in regulating cell proliferation and differentiation. SET is also involved in the regulation of renal cell proliferation and tumorigenesis. SET mRNA expression is markedly reduced in cells rendered quiescent by serum starvation, contact inhibition, or differentiation. SET protein expression is also much greater in developing rat and human kidney than in fully differentiated, mature kidney. High levels of SET mRNA and SET protein expression arefound in Wilms' tumor, but not in renal cell carcinoma, adult polycystic kidney disease or in transitional cell carcinoma.
抗原
-
You are here:
