Arachidonate 5-Lipoxygenase-Activating Protein (ALOX5AP) Peptide
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Quick Overview for Arachidonate 5-Lipoxygenase-Activating Protein (ALOX5AP) Peptide (ABIN2763850)
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宿主
资源
应用范围
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限制
- 仅限研究用
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储存条件
- -80 °C
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- ALOX5AP (Arachidonate 5-Lipoxygenase-Activating Protein (ALOX5AP))
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背景
- Seems to be required for the activation of 5-LO (5-lipoxygenase). Could play an essential role in the transfer of arachidonic acid to 5-LO. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes. Genetic variations in FLAP may be a cause of susceptibility to ischemic stroke [MIM:601367], also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.
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