Melanocortin 4 Receptor (MC4R) Peptide
MC4R
适用: 人, 大鼠, 小鼠
宿主: 合成
BP, WB, ICo, IDe
Quick Overview for Melanocortin 4 Receptor (MC4R) Peptide (ABIN2746856)
抗原
MC4R
(Melanocortin 4 Receptor (MC4R))
宿主
人, 大鼠, 小鼠
资源
合成
应用范围
Blocking Peptide (BP), Western Blotting (WB), Immunocompetition (ICo), Immunodepletion (IDe)
-
-
蛋白类型
- Synthetic
-
纯化方法
- Synthetic peptide
-
-
-
-
应用备注
- Optimal working dilution should be determined by the investigator.
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
储存条件
- -20 °C
-
储存方法
- For long-term storage of keep at -20 °C.
-
-
- MC4R (Melanocortin 4 Receptor (MC4R))
-
背景
- Melanocortin receptors are members of the rhodopsin family of 7-trans membrane G protein-coupled receptors that are involved in multiple signal transduction pathways including the cAMP and MAPK signaling pathways. These receptors are activated by members of the Melanocortin family: alpha-, beta- and Gammamelanocyte stimulating hormone (MSH) and adrenocorticotropic hormone (ACTH). The Melanocortins are involved in a wide range of physiological functions, including pigmentation, energy homeostasis, inflammation, immunomodulation, steroidogenesis and temperature control. There are five melanocortin receptor subtypes each of which has a different pattern of tissue expression with the relative potency of different melanocortin peptides. The melanocortin signaling system consists of two endogenous antagonists that bind specifically to the receptor but instead of activating they have an inhibitory effect. The antagonist proteins are termed agouti (or agouti signaling protein, ASP) and agouti-related protein (AGRP). Melanocortin-4 receptor (MC4R) transcripts are expressed primarily in the brain. Genetic studies of mice and humans established a critical role of MC4R in appetite regulation. MC4R has been implicated in weight regulation and defects in this gene are a cause of autosomal dominant obesity. Activation of MC4R results in the inhibition of c-Jun N-terminal kinase (JNK) activity and promotes insulin signaling. MC4R-null mice display maturity onset obesity characterized by hyperphagia, increased adiposity, hyperinsulinaemia and hyperleptinaemia, suggesting that obesity-linked gene, such as, MC4R is a potential candidate target for the treatment of obesity. Heterozygous mutations in MC4R account for 1-6 % of severe cases of human obesity. All known mammalian MC4Rs are 332 amino acids in length with an estimated molecular weight of 40 kDa. The protein is heavily glycosylated and appears at multiple positions on SDS-PAGE. The gene for MC4R is present on chromosome 18q22.
-
NCBI登录号
- NP_005903
-
UniProt
- P32245
抗原
-
You are here:
