Runt-Related Transcription Factor 1 (RUNX1) (N-Term) Peptide
RUNX1
适用: 人, 小鼠
宿主: 合成
BP, WB
产品编号 ABIN2185134
发货至:
中国
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Contact Info
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Quick Overview for Runt-Related Transcription Factor 1 (RUNX1) (N-Term) Peptide (ABIN2185134)
抗原
RUNX1
(Runt-Related Transcription Factor 1 (RUNX1))
宿主
人, 小鼠
资源
合成
应用范围
Blocking Peptide (BP), Western Blotting (WB)
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蛋白结构域
- N-Term
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序列
- KMSEALPLGA PDGGPALASK LRSGDRSMVE VLADHPGELV RTDSPNFLCS
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产品特性
- This is a synthetic peptide designed for use in combination with anti-Runx1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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纯化方法
- Purified
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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浓度
- 1 mg/mL
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缓冲液
- Final peptide concentration is 1 mg/mL in PBS.
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注意事项
- Avoid repeat freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- RUNX1 (Runt-Related Transcription Factor 1 (RUNX1))
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背景
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CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL-3 and GM-CSF promoters. Runx1 is essential for the development of normal hematopoiesis. Isoform 4 shows higher binding activities for target genes and binds TCR-beta-E2 and RAG-1 target site with threefold higher affinity than other isoforms. It is less effective in the context of neutrophil terminal differentiation. Runx1 acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the BLK promoter. It inhibits KAT6B-dependent transcriptional activation .
Alias Symbols: AI462102, AML1, Cbfa2, Pebp2a2, Pebpa2b
Protein Size: 387 -
分子量
- 42 kDa
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基因ID
- 12394
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NCBI登录号
- NM_009821, NP_033951
抗原
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