Telomerase Reverse Transcriptase (TERT) (C-Term) Peptide
TERT
适用: 人
宿主: 合成
BP, WB
产品编号 ABIN2182269
发货至:
中国
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Quick Overview for Telomerase Reverse Transcriptase (TERT) (C-Term) Peptide (ABIN2182269)
抗原
TERT
(Telomerase Reverse Transcriptase (TERT))
宿主
人
资源
合成
应用范围
Blocking Peptide (BP), Western Blotting (WB)
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蛋白结构域
- C-Term
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序列
- HQAFLLKLTR HRVTYVPLLG SLRTAQTQLS RKLPGTTLTA LEAAANPALP
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产品特性
- This is a synthetic peptide designed for use in combination with anti-TERT Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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纯化方法
- Purified
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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浓度
- 1 mg/mL
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缓冲液
- Final peptide concentration is 1 mg/mL in PBS.
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注意事项
- Avoid repeat freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- TERT (Telomerase Reverse Transcriptase (TERT))
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背景
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Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified, the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity.
Alias Symbols: DKCA2, DKCB4, EST2, TCS1, TP2, TRT, hEST2, hTRT
Protein Size: 1132 -
分子量
- 127 kDa
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基因ID
- 7015
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NCBI登录号
- NM_198253, NP_937983
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UniProt
- O14746
抗原
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