NEDD8 Activating Enzyme E1 Subunit 1 (NAE1) (C-Term) Peptide
NAE1
适用: 小鼠, 人
宿主: 合成
BP, WB
产品编号 ABIN1541277
发货至:
中国
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Contact Info
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Quick Overview for NEDD8 Activating Enzyme E1 Subunit 1 (NAE1) (C-Term) Peptide (ABIN1541277)
抗原
NAE1
(NEDD8 Activating Enzyme E1 Subunit 1 (NAE1))
宿主
小鼠, 人
资源
合成
应用范围
Blocking Peptide (BP), Western Blotting (WB)
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蛋白结构域
- C-Term
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序列
- ARALKEFVAK EGQGNLPVRG TIPDMIADSN KYIKLQNVYR EKAKKDAAAV
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产品特性
- This is a synthetic peptide designed for use in combination with anti-Nae1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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纯化方法
- Purified
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应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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浓度
- 1 mg/mL
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缓冲液
- Final peptide concentration is 1 mg/mL in PBS.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- NAE1 (NEDD8 Activating Enzyme E1 Subunit 1 (NAE1))
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背景
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Nae1 is a regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation.
Alias Symbols: 59 kDa, Appbp1
Protein Size: 534 -
分子量
- 60 kDa
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基因ID
- 234664
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NCBI登录号
- NM_144931, NP_659180
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UniProt
- Q8VBW6
抗原
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