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Chicken Monoclonal EXOC4 Primary Antibody for IF, IP - ABIN968093
Charron, Nakamura, Bacallao, Wandinger-Ness: Compromised cytoarchitecture and polarized trafficking in autosomal dominant polycystic kidney disease cells. in The Journal of cell biology 2000
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Chicken Monoclonal EXOC4 Primary Antibody for IF, IP - ABIN968092
Ting, Hazuka, Hsu, Kirk, Bean, Scheller: rSec6 and rSec8, mammalian homologs of yeast proteins essential for secretion. in Proceedings of the National Academy of Sciences of the United States of America 1995
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Human Monoclonal EXOC4 Primary Antibody for ELISA, WB - ABIN528409
Imai, Yoshie, Haga-Tsujimura, Nashida, Shimomura: Exocyst subunits are involved in isoproterenol-induced amylase release from rat parotid acinar cells. in European journal of oral sciences 2012
Human Polyclonal EXOC4 Primary Antibody for ICC, IF - ABIN4352426
Stadler, Rexhepaj, Singan, Murphy, Pepperkok, Uhlén, Simpson, Lundberg: Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells. in Nature methods 2013
Sec5 (显示 EXOC2 抗体), Sec6 (显示 EXOC3 抗体) and Sec8 act as a complex, each member dependent on the others for proper localization and function
No evidence that Sec8 is required for basal neurotransmission, though glutamate (显示 GRIN2A 抗体) receptor trafficking was mildly disrupted in sec8 mutants.
Sec8 regulates N-cadherin (显示 CDH2 抗体) expression by controlling Smad3 (显示 SMAD3 抗体) and Smad4 (显示 SMAD4 抗体) expression through CBP (显示 CREBBP 抗体), thereby mediating the epithelial-mesenchymal transition.
Sec8 regulate Bcl-2 (显示 BCL2 抗体) and Mcl-1 (显示 MCL1 抗体) expressions but not Bcl-xl (显示 BCL2L1 抗体) in malignant peripheral nerve sheath tumor cells.
Sec8 regulates histone-modifying proteins ATF2 (显示 ATF2 抗体) and RNF20 (显示 RNF20 抗体).
Sec8 knockdown in HSC3 cells resulted in reduced expressions of PAK1 (显示 PAK1 抗体) and PAK2 (显示 PAK2 抗体) by upregulating Pirh2 (显示 RCHY1 抗体) and Siah1 (显示 SIAH1 抗体) expression, which inhibited the ERK (显示 EPHB2 抗体) or p38 MAPK (显示 MAPK14 抗体) signalling pathway and cytokeratin8 phosphorylation and cell migration.
knockdown of Sec8 enhances the binding of JIP4 (显示 SPAG9 抗体) to MAPK (显示 MAPK1 抗体) kinase 4, thereby decreasing the phosphorylation of MAPK (显示 MAPK1 抗体) kinase 4, JNK (显示 MAPK8 抗体), and p38 (显示 CRK 抗体).
Exome sequencing revealed a likely pathogenic mutation in three novel candidate MKS (显示 MKS1 抗体) disease genes-C5orf42 (显示 C5ORF42 抗体), EVC2 (显示 EVC2 抗体) and SEC8 (also known as EXOC4), which encodes an exocyst protein with an established role in ciliogenesis
High Sec8 expression is associated with progression of oral squamous-cell carcinoma by secretion of matrix metalloproteinases.
EXOC4 is involved in insulin (显示 INS 抗体)-stimulated glucose transport and may be a candidate for an association with type 2 diabetes.
The exocyst subunits Sec3 (显示 EXOC1 抗体) and Sec8 interact with the polarity protein IQGAP1 (显示 IQGAP1 抗体) and that this interaction is triggered by active Cdc42 (显示 CDC42 抗体) and RhoA (显示 RHOA 抗体), which are essential for matrix degradation.
CREG1 (显示 CREG1 抗体) interacts with Sec8 to promote cardiomyogenic differentiation and cell-cell adhesion.
SAP102 (显示 DLG3 抗体) interacts with the PDZ (显示 INADL 抗体)-binding domain of Sec8, a member of the exocyst complex. Interactions between the two proteins are involved in the delivery of N-methyl-D-aspartate receptors to the cell surface in heterologous cells and neurons.
the exocyst complex serves to selectively regulate the docking of insulin (显示 INS 抗体)-containing vesicles at sites of release close to the plasma membrane
Sec8 controls the directional movement of AMPA (显示 GRIA3 抗体) receptors towards synapses through PDZ (显示 INADL 抗体)-dependent interactions.
Insulin (显示 INS 抗体) stimulates the phosphorylation of the exocyst protein Sec8 in adipocytes.
Interaction of Discs large 1 (Dlg1 (显示 DLG4 抗体)) with the Sec8 exocyst component promotes membrane addition, whereas with myotubularin-related protein 2 (Mtmr2 (显示 MTMR2 抗体)), negatively regulates membrane formation.
The amount of pectinaceous mucilage and seed coat structure in sec8 and exo70A1 exocyst mutants, was characterized.
An allelic series of six independent T-DNA mutations reveal a role for SEC8 in male gametophyte function.
SEC8 copurifies in a high molecular mass fraction of 900 kD, interacts with SEC6 (显示 EXOC3 抗体), and functions as a subunit in a exocyst complex that plays important roles in morphogenesis.
The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
, funnel cakes
, SEC8 protein
, exocyst complex component 4
, SEC8-like 1
, exocyst complex component Sec8
, augmenter of liver regeneration (ALR) pseudogene
, secretory protein SEC8