This gene encodes a member of the peptidase family. The protein forms a homodimer that hydrolyzes dipeptides or tripeptides with C-terminal proline or hydroxyproline residues. The enzyme serves an important role in the recycling of proline, and may be rate limiting for the production of collagen. Mutations in this gene result in prolidase deficiency, which is characterized by the excretion of large amount of di- and tri-peptides containing proline. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009].
Rešetar Maslov, Farkaš, Rubić, Kuleš, Beletić, Beer Ljubić, Šmit, Mrljak, Torti: "Serum Proteomic Profiles Reflect the Stages of Myxomatous Mitral Valve Disease in Dogs." in: International journal of molecular sciences, Vol. 24, Issue 8, (2023) (PubMed).
Surazynski, Donald, Cooper, Whiteside, Salnikow, Liu, Phang: "Extracellular matrix and HIF-1 signaling: the role of prolidase." in: International journal of cancer. Journal international du cancer, Vol. 122, Issue 6, pp. 1435-40, (2008) (PubMed).
Aliases for PEPD 抗体
peptidase D (pepd) 抗体 peptidase D (pepD) 抗体 peptidase D (PEPD) 抗体 peptidase D L homeolog (pepd.L) 抗体 peptidase D (Pepd) 抗体 cb1000 抗体 DDBDRAFT_0190220 抗体 DDBDRAFT_0266378 抗体 DDB_0190220 抗体 DDB_0266378 抗体 fj78g11 抗体 MGC89151 抗体 Pep-4 抗体 Pep4 抗体 PROLIDASE 抗体 prolidase 抗体 wu:fj78g11 抗体