This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The encoded protein consists of an extracellular domain containing 7 cadherin repeats, a transmembrane domain and a cytoplasmic tail that differs from those of the classical cadherins. The gene is located in a major X/Y block of homology and its most closely related cadherin superfamily member is located in this homologous region on the X chromosome. The protein is thought to play a fundamental role in cell-cell recognition essential for the segmental development and function of the central nervous system. Transcripts arising from alternative splicing encode isoforms with N- and C-terminal variation. [provided by RefSeq, Jul 2008].
Kalmady, Venkatasubramanian: "Evidence for positive selection on Protocadherin Y gene in Homo sapiens: implications for schizophrenia." in: Schizophrenia research, Vol. 108, Issue 1-3, pp. 299-300, (2009) (PubMed).