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Mouse (Murine) p300 ELISA Kit for Sandwich ELISA - ABIN425425
Feng, Cao, Chen, Chu, Chu, Chakrabarti: miR-200b Mediates Endothelial-to-Mesenchymal Transition in Diabetic Cardiomyopathy. in Diabetes 2016
Two possible modes of pioneering associated with combinations of H2A.Z (显示 H2AFZ ELISA试剂盒) and p300/CBP (显示 CREBBP ELISA试剂盒) at nucleosome-occupied enhancers.
these results demonstrate that the reversible acetylation of FOXM1 (显示 FOXM1 ELISA试剂盒) by p300/CBP (显示 CREBBP ELISA试剂盒) and SIRT1 (显示 SIRT1 ELISA试剂盒) modulates its transactivation function
Ectopic expression of EP300-ZNF384 (显示 ZNF384 ELISA试剂盒) and CREBBP (显示 CREBBP ELISA试剂盒)-ZNF384 (显示 ZNF384 ELISA试剂盒) fusion altered differentiation of mouse hematopoietic stem and progenitor cells and also potentiated oncogenic transformation in vitro.our results indicate that gene fusion is a common class of genomic abnormalities in childhood ALL and that recurrent translocations involving EP300 and CREBBP (显示 CREBBP ELISA试剂盒) may cause epigenetic deregulation with potential for therapeutic targeting.
p300 inhibition attenuates both thrombin (显示 F2 ELISA试剂盒) induced-CCL2 (显示 CCL2 ELISA试剂盒) expression and histone H3 (显示 HIST3H3 ELISA试剂盒) and H4 acetylation in HLFs, suggesting that p300 is involved in thrombin (显示 F2 ELISA试剂盒)-induced CCL2 (显示 CCL2 ELISA试剂盒) expression via hyperacetylating histone H3 (显示 HIST3H3 ELISA试剂盒) and H4.
p300-dependent histone H3 (显示 HIST3H3 ELISA试剂盒) acetylation and C/EBPbeta (显示 CEBPB ELISA试剂盒)-regulated IKKbeta (显示 IKBKB ELISA试剂盒) expression contribute to thrombin (显示 F2 ELISA试剂盒)-induced IL-8/CXCL8 (显示 IL8 ELISA试剂盒) expression in human lung epithelial cells.
MnTE-2-PyP (显示 PPA1 ELISA试剂盒) decreased p300 complex binding to a specific HRE motif within the PAI-1 (显示 SERPINE1 ELISA试剂盒) gene promoter region, suppressed H3K9 acetylation, and consequently, repressed PAI-1 (显示 SERPINE1 ELISA试剂盒) expression. Mechanistically, less p300 transcriptional complex binding is not due to the reduction of binding between p300 and HIF-1 (显示 HIF1A ELISA试剂盒)/CREB (显示 CREB1 ELISA试剂盒) transcription factors, but through inhibiting the binding of HIF-1 (显示 HIF1A ELISA试剂盒)/CREB (显示 CREB1 ELISA试剂盒) transcription factors to DNA
High p300 expression is associated with prostate cancer growth.
Understanding the effects of disrupting the acetyltransferase activity of CBP/p300 (显示 CREBBP ELISA试剂盒) could pave the way for new therapeutic approaches to treat patients with these diseases
How cancer cells use p300/CBP (显示 CREBBP ELISA试剂盒) in their favor varies depending on the cellular context and is evident by the growing list of loss- and gain-of-function genetic alterations in p300 and CBP (显示 CREBBP ELISA试剂盒) in solid tumors and hematological malignancies.[review]
CREBBP (显示 CREBBP ELISA试剂盒) and EP300 mutations remained significant to predict worse OS, PFS, and EFS (显示 EFS ELISA试剂盒).
Here the authors report a lipopolysaccharide-induced NFkappaB enhanceosome in which TonEBP (显示 NFAT5 ELISA试剂盒) is required for the recruitment of p300 (显示 NOTCH1 ELISA试剂盒). Increased expression of TonEBP (显示 NFAT5 ELISA试剂盒) enhances the NFkappaB activity and reduced TonEBP (显示 NFAT5 ELISA试剂盒) expression lowers it.
Enhancer-priming by MLL3/MLL4 (显示 MLL4 ELISA试剂盒) followed by enhancer-activation by CBP/p300 (显示 CREBBP ELISA试剂盒) sequentially shape dynamic enhancer landscapes during cell differentiation
Data show that LPS (显示 TLR4 ELISA试剂盒) induces endoplasmic reticulum (ER) stress and P300 (显示 NOTCH1 ELISA试剂盒) activity via the XBP1 (显示 XBP1 ELISA试剂盒)/IRE1 (显示 ERN1 ELISA试剂盒) pathway.
Loss of p300 (显示 NOTCH1 ELISA试剂盒) expression is associated with leukemogenesis.
UTX (显示 KDM6A ELISA试剂盒)-MLL4 (显示 MLL4 ELISA试剂盒)-p300 (显示 NOTCH1 ELISA试剂盒) transcriptional regulatory network establishing an "active enhancer landscape" and defines a detailed mechanism for the joint deposition of H3K4me1 and H3K27ac.
Acetylation-dependent control of global poly(A) RNA degradation by CBP/p300 (显示 CREBBP ELISA试剂盒) and HDAC1-HDAC2 (显示 HDAC1 ELISA试剂盒) has been described.
Data, including data from studies in cells from knockout mice, suggest that Prmt1 (显示 PRMT1 ELISA试剂盒) activity was necessary for c-Myc (显示 MYC ELISA试剂盒) binding to acetyltransferase p300 (显示 NOTCH1 ELISA试剂盒) in myeloid cells; Prmt1 (显示 PRMT1 ELISA试剂盒) inhibition decreases p300 (显示 NOTCH1 ELISA试剂盒) recruitment to c-Myc (显示 MYC ELISA试剂盒) target promoters and increased Hdac1 (显示 HDAC1 ELISA试剂盒) recruitment. [Prmt1 (显示 PRMT1 ELISA试剂盒), protein arginine N-methyltransferase 1 (显示 PRMT1 ELISA试剂盒); c-Myc (显示 MYC ELISA试剂盒) = Proto-Oncogene (显示 RAB1A ELISA试剂盒) Proteins c-myc (显示 MYC ELISA试剂盒); Hdac1 (显示 HDAC1 ELISA试剂盒) = histone deacetylase 1 (显示 HDAC1 ELISA试剂盒)]
In line with the acetyltransferase activity of p300 (显示 NOTCH1 ELISA试剂盒), H3K27 acetylation was reduced after HDACi and resulted in the formation of heterochromatin in the PTGES1 gene. In conclusion, HDAC (显示 HDAC3 ELISA试剂盒) activity maintains PTGES1 expression by recruiting p300 (显示 NOTCH1 ELISA试剂盒) to its gene
ARX positively regulates Wnt (显示 WNT2 ELISA试剂盒)/ beta-catenin (显示 CTNNB1 ELISA试剂盒) signaling and the C-terminal domain of ARX interacts with the armadillo (显示 PKP1 ELISA试剂盒) repeats in beta-catenin (显示 CTNNB1 ELISA试剂盒) to promote Wnt (显示 WNT2 ELISA试剂盒)/beta-catenin (显示 CTNNB1 ELISA试剂盒) signaling. In addition, we found BCL9 (显示 BCL9 ELISA试剂盒) and P300 (显示 NOTCH1 ELISA试剂盒) also interact with ARX to modulate Wnt (显示 WNT2 ELISA试剂盒)/beta-catenin (显示 CTNNB1 ELISA试剂盒) signaling.
2-O, 3-O desulfated heparin inhibited HMGB1 (显示 HMGB1 ELISA试剂盒) release, at least in part, by direct molecular inhibition of p300 HAT activity.
This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer.
histone acetyltransferase p300
, histone acetyltransferase
, E1A binding protein p300
, histone acetyltransferase p300-like
, E1A-associated protein p300
, E1A-binding protein, 300kD
, p300 HAT