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抗Human C-MYC 抗体:
抗Rat (Rattus) C-MYC 抗体:
抗Mouse (Murine) C-MYC 抗体:
Human Monoclonal C-MYC Primary Antibody for FM, IHC (fro) - ABIN967320
Blackwood, Eisenman: Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc. in Science (New York, N.Y.) 1991
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Chicken Monoclonal C-MYC Primary Antibody for ChIP, CyTOF - ABIN152253
Locker, Dowle, Ellis, Elston, Blamey, Sikora, Evan, Robins: c-myc oncogene product expression and prognosis in operable breast cancer. in British journal of cancer 1989
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Human Monoclonal C-MYC Primary Antibody for FACS, IHC (p) - ABIN302092
Veracini, Simon, Richard, Schraven, Horejsi, Roche, Benistant: The Csk-binding protein PAG regulates PDGF-induced Src mitogenic signaling via GM1. in The Journal of cell biology 2008
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Human Monoclonal C-MYC Primary Antibody for FACS, IHC (p) - ABIN302017
Wang, Campoli, Ko, Luo, Ferrone: Enhancement of scFv fragment reactivity with target antigens in binding assays following mixing with anti-tag monoclonal antibodies. in Journal of immunological methods 2004
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All Species Monoclonal C-MYC Primary Antibody for FACS, IP - ABIN2749043
Persson, Hennighausen, Taub, DeGrado, Leder: Antibodies to human c-myc oncogene product: evidence of an evolutionarily conserved protein induced during cell proliferation. in Science (New York, N.Y.) 1984
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All Species Monoclonal C-MYC Primary Antibody for IHC, IHC (p) - ABIN4994828
Hilpert, Hansen, Wessner, Küttner, Welfle, Seifert, Höhne: Anti-c-myc antibody 9E10: epitope key positions and variability characterized using peptide spot synthesis on cellulose. in Protein engineering 2001
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Human Monoclonal C-MYC Primary Antibody for FACS, IHC (p) - ABIN536092
Fujiwara, Poikonen, Aleman, Valtavaara, Saksela, Mayer: A single-chain antibody/epitope system for functional analysis of protein-protein interactions. in Biochemistry 2002
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Human Monoclonal C-MYC Primary Antibody for IHC (fro), IF - ABIN2477762
Quant, Woo: Normal values of eye position in the Chinese population of Hong Kong. in Optometry and vision science : official publication of the American Academy of Optometry 1992
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Human Polyclonal C-MYC Primary Antibody for IF (cc), IF (p) - ABIN1387773
Gao, Zhao, Song, Yang: Expression pattern of embryonic stem cell markers in DFAT cells and ADSCs. in Molecular biology reports 2012
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This beta-catenin (显示 CTNNB1 抗体)-mediated activation of PHB (显示 PHB 抗体) expression was independent of cMYC activation, a product of Wnt (显示 WNT2 抗体) signaling.These data indicate that PHB (显示 PHB 抗体) is a direct target of beta-catenin (显示 CTNNB1 抗体) and the increased level of PHB (显示 PHB 抗体) in leukemia can be regulated by Wnt (显示 WNT2 抗体) signaling
HOMO (显示 AKAP1 抗体)SAPIENS AND
Studies showed that MYC amplification is present in 30-50% of high-grade breast cancers. MYC-dependent pathways are often elevated in acquired resistance to anti-cancer therapies and can be used as a useful predictive marker for drug resistance in breast cancer. [review]
c-Myc, a downstream key effector of BRAF (显示 BRAF 抗体)(V600E) signaling, was required for BRAF (显示 BRAF 抗体)(V600E)-induced changes in lysine27-trimethylated histone H3 (显示 HIST3H3 抗体) through regulating the components of the polycomb (显示 CBX2 抗体) repressive complex 2 (PRC2) genes Ezh2 (显示 EZH2 抗体), Suz12 and Jarid2 (显示 JARID2 抗体) at both transcriptional levels via direct binding to their regulatory elements and post-transcriptional levels via repressing the miR (显示 MLXIP 抗体)-26a, miR (显示 MLXIP 抗体)-200b and miR (显示 MLXIP 抗体)-155.
Human c-myc suppresses poly(Q)-mediated neurotoxicity in Drosophila disease model.
The human cMyc gene, when expressed in Drosophila, impedes activated JNK signaling-induced cell death. O (显示 MAPK8 抗体)nly the longest isoform c-Myc1, but not the truncated c-Myc2 or c-MycS, c (显示 MAPK8 抗体)ould suppress GMR>Egr triggered small eye phenotype. Be (显示 MAPK8 抗体)sides its well-studied apop (显示 MAPK8 抗体)tosis promoting function, Myc also antagonizes JNK-mediated cell death in Drosophila, and this function is likely conserved from fly to human.
we have identified that Myc is a key regulator of the RU/RR dichotomy in TNBC, which is in turn linked to stem-like features in these tumors.
the biochemical and structural results presented here reveal that Myc and CaM directly interact with each other, and further analyses are required to elucidate in detail the molecular mechanisms of functional interconnections between Myc regulatory pathways and Ca2 (显示 CA2 抗体)+ second messenger signaling.
findings further support the importance of MYC in CLL/SLL (显示 SLC35B2 抗体) and the hypothesis that upstream mediators of MYC protein expression, rather than intrinsic abnormalities of the MYC gene, are responsible for its expression in proliferation centers
In AML (显示 RUNX1 抗体) patients, low level of miR (显示 MLXIP 抗体)-451 is negatively correlated with high levels of c-Myc and YWHAZ (显示 YWHAZ 抗体), while c-Myc level is positively related to YWHAZ (显示 YWHAZ 抗体) expression. These results suggested that c-Myc dash, verticalmiR-451 dash, verticalYWHAZ/AKT (显示 AKT1 抗体) cascade might play a crucial role during leukemogenesis, and reintroduction of miR (显示 MLXIP 抗体)-451 could be as a potential strategy for AML (显示 RUNX1 抗体) therapy.
Ouabain-induced proliferation might be attributed, at least in part, to decrease of intracellular free calcium and increase of c-myc mRNA expression, and that may be directly or indirectly involved in regulation of blood pressure.
report the isolation of complete coding regions of rabbit SOX2, KLF4, C-MYC and NANOG, which encode transcription factors that play crucial regulatory roles during early mammalian embryonic development
AKAP1 (显示 AKAP1 抗体) is a transcriptional target of Myc, and it supports mTOR (显示 FRAP1 抗体) pathway and the growth of cancer cells.
Spermatogonial stem cells and progenitors are refractory to reprogramming to pluripotency by the transcription factors Oct3/4 (显示 POU5F1 抗体), c-Myc, Sox2 (显示 SOX2 抗体) and Klf4 (显示 KLF4 抗体).
High c-myc expression is associated with gliomagenesis.
In a mouse lung model of KRas(G12D)-driven adenomas, co-activation of Myc drives the immediate transition to highly proliferative and invasive adenocarcinomas marked by highly inflammatory, angiogenic, and immune-suppressed stroma.
the role of phosphorylation on AID serine38 in AID activity at the Immunoglobulin switch region and off-target Myc gene, is reported.
This study demonstrates that LMP2A uses the role of MYC in the cell cycle, particularly in the p27(kip1 (显示 CDKN1B 抗体)) degradation process, to accelerate lymphomagenesis in vivo.
Results show Myc to be dispensable for sustained in vivo hepatocyte proliferation but necessary for maintaining normal lipid homeostasis.
Data show that the induction of BIM (显示 BCL2L11 抗体) in the MYC- and RAS-driven leukemia is mediated by the downregulation of miR-17-92, and suggest that induction of BIM (显示 BCL2L11 抗体)-mediated apoptosis may be a therapeutic approach for acute lymphoblastic leukemia (ALL).
Pin1 (显示 PIN1 抗体) silencing in lymphomas retarded disease progression in mice, making Pin1 (显示 PIN1 抗体) an attractive therapeutic target in Myc-driven tumors.
beta-catenin (显示 CTNNB1 抗体) cooperates with the transcription factor Myc to activate the progenitor renewal program.
Apoptosis was also observed with myca expression; introduction of homozygous tp53 (显示 TP53 抗体)(-/-) mutation into the myca transgenic fish reduced apoptosis and accelerated tumor progression.
MYC down-regulation induces mitochondrial apoptosis in T lymphoblasts.
These findings not only reveal a novel role of Mad1 (显示 MXD1 抗体) in regulating developmental cell death but also suggest that a balance of Mad and Myc controls cell fate determination during adult organ development.
Thyroid hormone (显示 PTH 抗体) activates protein arginine methyltransferase 1 expression by directly inducing c-Myc transcription during Xenopus intestinal stem cell development.(
c-Myc has a direct role in the control of DNA replication
Findings support a model in which Myc, Twist and Slug/Snail2 function in a regulatory circuit within lateral plate mesoderm that directs normal vessel formation in both the vascular and lymphatic systems.
Expression of Drosophila Myc (dMyc) suppresses, whereas loss of dMyc enhances, ectopically activated JNK (显示 MAPK8 抗体) signaling-induced cell death. dMyc impedes physiologically activated JNK (显示 MAPK8 抗体) pathway-mediated cell death. Loss of dMyc triggers JNK (显示 MAPK8 抗体) pathway activation and JNK (显示 MAPK8 抗体)-dependent cell death.
tissue-specific downregulation of the Drosophila homolog of human c-myc proto-oncogene (dMyc) suppresses tau-mediated morphological and functional deficits by reducing abnormal tau hyperphosphorylation and restoring the heterochromatin loss.
dMyc has an essential role in preventing JNK (显示 MAPK8 抗体)-mediated retinal glial activation
the key target of the Psi/MED network in controlling developmentally regulated tissue growth is the transcription factor MYC.
Myc dosage plays crucial role in determining sex-specific size in Drosophila larvae and adult tissue. Double dose of Myc in females serves at least twice in development to promote sexual size dimorphism.
BicC (显示 BICC1 抗体) down regulates Myc in the Malpighian tubule.
activation of the TOR-Myc axis in midgut stem and progenitor cells influences a variety of traits in Drosophila
Drosophila adult muscle precursors display homing behavior to muscle niche and the niche-driven Insulin (显示 INS 抗体)-Notch (显示 NOTCH1 抗体)-dMyc cascade plays a key role in setting the activated state of adult muscle precursors.
a functional link between Myc, a renowned oncogene (显示 RAB1A 抗体), and the essential nucleotide biosynthetic enzyme CTPsyn.
MYC and S6K (显示 RPS6KB1 抗体) cooperate through coordinate activation of the essential Pol I transcription initiation factor TIF-1A (显示 RRN3 抗体).
The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene.
avian myelocytomatosis viral oncogene homolog
, class E basic helix-loop-helix protein 39
, myc proto-oncogene protein
, myc-related translation/localization regulatory factor
, proto-oncogene c-Myc
, transcription factor p64
, v-myc myelocytomatosis viral oncogene homolog
, c-myc proto-oncogene
, avian myelocytomatosis viral (v-myc) oncogene homolog
, Avian myelocytomatosis viral (v-myc) oncogene homolog
, myelocytomatosis viral oncogene homolog
, v-myc avian myelocytomatosis viral oncogene homolog
, cellular myelocytomatosis oncogene
, Proto-oncogene c-Myc
, Transcription factor p64
, transcriptional regulator Myc-A
, MYC II
, transcriptional regulator Myc-B
, Myc proto-oncogene protein
, CG10798 gene product from transcript CG10798-RB
, Diminutive protein
, lethal (1) G0354
, lethal (1) G0359