(Prolyl 4-Hydroxylase, alpha Polypeptide II (P4HA2))
This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008].
Gilkes, Bajpai, Chaturvedi, Wirtz, Semenza: "Hypoxia-inducible factor 1 (HIF-1) promotes extracellular matrix remodeling under hypoxic conditions by inducing P4HA1, P4HA2, and PLOD2 expression in fibroblasts." in: The Journal of biological chemistry, Vol. 288, Issue 15, pp. 10819-29, (2013) (PubMed).
Gilkes, Chaturvedi, Bajpai, Wong, Wei, Pitcairn, Hubbi, Wirtz, Semenza: "Collagen prolyl hydroxylases are essential for breast cancer metastasis." in: Cancer research, Vol. 73, Issue 11, pp. 3285-96, (2013) (PubMed).
Berger, Capper, Lemke, Pfenning, Platten, Weller, von Deimling, Wick, Weiler: "Defective p53 antiangiogenic signaling in glioblastoma." in: Neuro-oncology, Vol. 12, Issue 9, pp. 894-907, (2010) (PubMed).