This gene encodes a protein that binds to the polyA tail found at the 3' end of most eukaryotic mRNAs. It is thought to play a role in the regulation of mRNA metabolic processes in the cytoplasm. This gene is located in a gene-poor region within the X-specific 13d-sY43 subinterval of the chromosome Xq21.3/Yp11.2 homology block. It is located close to translocation breakpoints associated with premature ovarian failure, and is therefore a potential candidate gene for this disorder. [provided by RefSeq, May 2010].
Bhattacharjee, Bag: "Depletion of nuclear poly(A) binding protein PABPN1 produces a compensatory response by cytoplasmic PABP4 and PABP5 in cultured human cells." in: PLoS ONE, Vol. 7, Issue 12, pp. e53036, (2013) (PubMed).
Mulder, Wernérus, Shi, Pontén, Hober, Uhlén, Hökfelt: "Systematically generated antibodies against human gene products: high throughput screening on sections from the rat nervous system." in: Neuroscience, Vol. 146, Issue 4, pp. 1689-703, (2007) (PubMed).