The obscurin gene spans more than 150 kb, contains over 80 exons and encodes a protein of approximately 720 kDa. The encoded protein contains 68 Ig domains, 2 fibronectin domains, 1 calcium/calmodulin-binding domain, 1 RhoGEF domain with an associated PH domain, and 2 serine-threonine kinase domains. This protein belongs to the family of giant sacromeric signaling proteins that includes titin and nebulin, and may have a role in the organization of myofibrils during assembly and may mediate interactions between the sarcoplasmic reticulum and myofibrils. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].
Hu, Kontrogianni-Konstantopoulos: "The kinase domains of obscurin interact with intercellular adhesion proteins." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 27, Issue 5, pp. 2001-12, (2013) (PubMed).