NUAK1 产品
(NUAK Family, SNF1-Like Kinase, 1 (NUAK1))
Categories
Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. Phosphorylates ATM, CASP6, LATS1, PPP1R12A and p53/TP53. Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of 'Ser-464' of LATS1, thereby controlling its stability. Controls cell adhesion by regulating activity of the myosin protein phosphatase 1 (PP1) complex. Acts by mediating PPP1R12A then interacts with 14-3-3, leading to reduced dephosphorylation of myosin MLC2 by myosin PP1. May be involved in 392' and is recruited to the CDKN1A/WAF1 promoter to participate to transcription activation by p53/TP53. May also act as a tumor malignancy-associated factor by promoting tumor invasion and metastasis under regulation and phosphorylation by AKT1. Suppresses Fas-induced apoptosis by mediating phosphorylation of CASP6, thereby suppressing the activation of the caspase and the subsequent cleavage of CFLAR.
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Featured NUAK1 Categories
Recommended NUAK1 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
ELISA, IHC (p), IF (cc), IF (p), IHC (fro)
Validations
- (2)
Cat. No.
ABIN716396
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF
Validations
- (2)
Cat. No.
ABIN523287
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Hamster, Human, Mouse
Application
WB, IHC (p)
Validations
- (1)
- (2)
Cat. No.
ABIN392639
Quantity
400 μL
Datasheet
Datasheet
Recommended NUAK1 ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6227500
Quantity
96 tests
Datasheet
Datasheet
Recommended NUAK1 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Insect cells (Sf21)
Validations
- (2)
Cat. No.
ABIN5569713
Quantity
5 μg
Datasheet
Datasheet
Reactivity
Human
Source
Insect cells (Sf9)
Validations
- (2)
Cat. No.
ABIN5569712
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1313130
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our NUAK1 Products
: "Regulation of ploidy and senescence by the AMPK-related kinase NUAK1." in: The EMBO journal, Vol. 29, Issue 2, pp. 376-86, (2010) (PubMed).: "The changing AMPK expression profile in differentiating mouse skeletal muscle myoblast cells helps confer increasing resistance to apoptosis." in: Experimental physiology, Vol. 92, Issue 1, pp. 207-17, (2007) (PubMed).
: "ARK5 is a tumor invasion-associated factor downstream of Akt signaling." in: Molecular and cellular biology, Vol. 24, Issue 8, pp. 3526-35, (2004) (PubMed).
: "Strong association of ARK5 with tumor invasion and metastasis." in: Journal of experimental & clinical cancer research : CR, Vol. 23, Issue 2, pp. 263-8, (2004) (PubMed).
: "ARK5 suppresses the cell death induced by nutrient starvation and death receptors via inhibition of caspase 8 activation, but not by chemotherapeutic agents or UV irradiation." in: Oncogene, Vol. 22, Issue 40, pp. 6177-82, (2003) (PubMed).
: "Identification of a novel protein kinase mediating Akt survival signaling to the ATM protein." in: The Journal of biological chemistry, Vol. 278, Issue 1, pp. 48-53, (2002) (PubMed).
Synonyms and alternative names related to NUAK1
NUAK family kinase 1 (NUAK1), NUAK family, SNF1-like kinase, 1 (Nuak1), ARK5, AU014801, AW494241, B230104P22Rik, Omphk1Protein level used designations for NUAK1
- AMP-activated protein kinase family member 5
- AMPK-related protein kinase 5
- NUAK family SNF1-like kinase 1
- omphalocele kinase 1
- ZNUAK family, SNF1-like kinase, 1
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- Nucleaoside Diphosphate Kinase
- Nuclear Antigen
- Nuclear Casein Kinase and Cyclin-Dependent Kinase Substrate 1
- Nuclear Factor 1
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